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Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC

Saraya, Takeshi ; Tanabe, Koichi ; Araki, Koji ; [et al.]

American Society for Microbiology ; 2014

In: Journal of Clinical Microbiology Vol. 52, No. 7 ( 2014-07), p. 2709-2712

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In: Journal of Clinical Microbiology, American Society for Microbiology, Vol. 52, No. 7 ( 2014-07), p. 2709-2712

Abstract: Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from 〈 0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1 .

Type of Medium: Online Resource

ISSN: 0095-1137 , 1098-660X

URL: Article

DOI: 10.1128/JCM.03593-13

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2014

detail.hit.zdb_id: 1498353-9

SSG: 12