In:
Journal of Virology, American Society for Microbiology, Vol. 77, No. 7 ( 2003-04), p. 4396-4400
Abstract:
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8 + cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8 + lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8 + lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8 + lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.
Type of Medium:
Online Resource
ISSN:
0022-538X
,
1098-5514
DOI:
10.1128/JVI.77.7.4396-4400.2003
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2003
detail.hit.zdb_id:
1495529-5