In:
mBio, American Society for Microbiology, Vol. 1, No. 3 ( 2010-08-31)
Abstract:
Pseudomonas aeruginosa is the predominant airway pathogen causing morbidity and mortality in individuals affected by the genetic disease cystic fibrosis. P . aeruginosa can also cause severe pneumonia, burn wound infections, and sepsis, making its overall impact on human health significant. The attachment of P . aeruginosa to host tissues, often leading to recalcitrant biofilm infections, and inflammation induced by flagellin are both important mechanisms of virulence. We explored the role of the biofilm polysaccharide Psl in the pathogenesis of P . aeruginosa and found that Psl is required for surface adherence to A549 epithelial cells, and as an adhesin, it facilitates flagellin-mediated NF-κB activation. This work was done to better understand the initial events of infection and revealed that a biofilm polysaccharide contributes to inflammation in a novel manner.
Type of Medium:
Online Resource
ISSN:
2161-2129
,
2150-7511
DOI:
10.1128/mBio.00140-10
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2010
detail.hit.zdb_id:
2557172-2