In:
mBio, American Society for Microbiology, Vol. 9, No. 1 ( 2018-03-07)
Kurzfassung:
Glycosylation of host cell surface varies with species and location in the body, thus contributing to species specificity and tropism of microorganisms. Cross talk by Shigella , the Gram-negative enteroinvasive bacterium responsible for bacillary dysentery, with its exclusively human host has been extensively studied. However, the molecular determinants of the step of binding to host cells are poorly defined. Taking advantage of the observation that human-activated CD4 + T lymphocytes, but not nonactivated cells, are targets of Shigella , we succeeded in rendering the refractory cells susceptible to targeting upon loading of their plasma membrane with sialylated glycosphingolipids (gangliosides) that are abundantly present on activated cells. We show that interactions between the sugar polar part of gangliosides and the polysaccharide moiety of Shigella lipopolysaccharide (LPS) promote bacterial binding, which results in the injection of effectors via the type III secretion system. Whereas LPS interaction with gangliosides was proposed long ago and recently extended to a large variety of glycans, our findings reveal that such glycan-glycan interactions are critical for Shigella pathogenesis by driving selective interactions with host cells, including immune cells.
Materialart:
Online-Ressource
ISSN:
2161-2129
,
2150-7511
DOI:
10.1128/mBio.02309-17
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2018
ZDB Id:
2557172-2