In:
mBio, American Society for Microbiology
Abstract:
Elongation factor thermo-unstable (EF-Tu) is a universally conserved translation factor that mediates productive interactions between tRNAs and the ribosome. In bacteria, EF-Tu also delivers transfer-messenger RNA (tmRNA)-SmpB to the ribosome during trans -translation. We report the first small molecule, KKL-55, that specifically inhibits EF-Tu activity in trans -translation without affecting its activity in normal translation. KKL-55 has broad-spectrum antibiotic activity, suggesting that compounds targeted to the tmRNA-binding interface of EF-Tu could be developed into new antibiotics to treat drug-resistant infections.
Type of Medium:
Online Resource
ISSN:
2150-7511
DOI:
10.1128/mbio.01461-23
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2023
detail.hit.zdb_id:
2557172-2