In:
Collection of Czechoslovak Chemical Communications, Institute of Organic Chemistry & Biochemistry, Vol. 64, No. 2 ( 1999), p. 299-312
Abstract:
A series of ring-opened analogs of indomethacin was synthesized and tested in vitro (at concentrations ranging from 10 -9 to 10 -5 mol/l) on human neutrophil functions. Two compounds lacking the carboxylic group were subjected to the same tests and one of these showed unexpected activity. Among the acidic derivatives, compound 12 bearing the same substituents as indomethacin 10 (methoxy and 4-chlorobenzoyl groups) was the most active: it significantly lowered neutrophil responses in all five bioassays and at the three concentrations considered.
Type of Medium:
Online Resource
ISSN:
0010-0765
,
1212-6950
DOI:
10.1135/cccc19990299
Language:
English
Publisher:
Institute of Organic Chemistry & Biochemistry
Publication Date:
1999