In:
BMJ Case Reports, BMJ, Vol. 14, No. 6 ( 2021-06), p. e236061-
Abstract:
Human herpesvirus-8 (HHV8) is a recognised precursor for a number of neoplastic and non-neoplastic processes. Immunosuppressed recipients of both solid organ and haematopoietic stem cell transplants are at risk of life-threatening lytic reactivations of HHV8-infected B-lymphocytes, primary infections after receiving grafts from HHV8-seropositive donors and more rarely by the direct transplantation of malignant Kaposi sarcoma cells seeded within graft tissue. We describe the case of an HHV8-seronegative patient with confirmed, post-orthotopic liver transplant transmission of HHV8 from a seropositive donor with quantitative evidence of viraemia and subsequent development of disseminated visceral and cutaneous Kaposi sarcoma with a rapidly fatal outcome.
Type of Medium:
Online Resource
ISSN:
1757-790X
DOI:
10.1136/bcr-2020-236061
Language:
English
Publisher:
BMJ
Publication Date:
2021
detail.hit.zdb_id:
2467301-8
