In:
BMJ Open, BMJ, Vol. 11, No. 7 ( 2021-07), p. e048411-
Kurzfassung:
Knee osteoarthritis (OA) is associated with chronic knee pain and
functional disability that negatively affect the ability to carry out normal daily activities. Patients are offered a large variety of
non-surgical treatments, often not in accordance with clinical guidelines. This observational study will provide a comprehensive
overview of treatment pathways for knee OA during the first 2 years after consulting an orthopaedic surgeon, including timing and order of
treatment modalities, predictors of treatment outcomes, cost-effectiveness of treatment pathways and patients’ views on
different treatment pathways. Methods and analysis Patients with primary referrals to an orthopaedic surgeon due to
knee OA are consecutively invited to participate and fill out a questionnaire prior to their consultation with an orthopaedic surgeon.
Follow-up questionnaires will be obtained at 6 and 24 months after inclusion. Based on a prospective cohort study design, including
questionnaires and register data, we will (1) describe treatment pathways for knee OA during the first 2 years after consulting an
orthopaedic surgeon; (2) describe the characteristics of patients choosing different treatment pathways; (3) develop predictive models for
patient-self-determined classifications of good and poor treatment outcomes; (4) evaluate the cost-effectiveness of treatment pathways that
live up to clinical guidelines versus pathways that do not; based on a qualitative study design using semistructured individual interviews, we
will (5) describe the patients’ perspectives on treatment pathways for knee OA. Ethics and dissemination The study is approved by the Danish regional ethical committee
(journal number H-17017295) and the Danish Data Protection Agency (journal number AHH-2017–072). Data will be anonymised and handled in
line with the General Data Protection Regulation and the Danish Data Protection Act. The study results will be submitted to international
open-access peer-reviewed journals and disseminated at conferences. Trial registration number NCT03746184 , pre-results.
Materialart:
Online-Ressource
ISSN:
2044-6055
,
2044-6055
DOI:
10.1136/bmjopen-2020-048411
Sprache:
Englisch
Verlag:
BMJ
Publikationsdatum:
2021
ZDB Id:
2599832-8