In:
Lupus Science & Medicine, BMJ, Vol. 9, No. 1 ( 2022-11), p. e000779-
Abstract:
Infection is a major cause of death in patients with SLE. This study aimed to explore the infection rate in patients with SLE receiving a low dose of intravenous cyclophosphamide (IV-CYC). Methods Clinical parameters of 1022 patients with SLE from 24 hospitals in China were collected. Patients were divided into the short-interval and lower-dose (SILD, 400 mg every 2 weeks) IV-CYC group and the high-dose (HD, 500 mg/m 2 of body surface area every month) IV-CYC group. The clinical data and infection rate between the two groups were compared. Results Compared with HD IV-CYC, the infection rate of the SILD IV-CYC group was significantly lower (13.04% vs 22.27%, p=0.001). Respiratory tract infection (10.28% vs 15.23%, p=0.046) and skin/soft tissue infection (1.78% vs 4.3%, p=0.040) were significantly decreased in the SILD IV-CYC group. Moreover, infections occurred most likely in patients with SLE with leucopenia (OR 2.266, 95% CI 1.322 to 3.887, p=0.003), pulmonary arterial hypertension (OR 2.756, 95% CI 1.249 to 6.080, p=0.012) and 〉 15 mg/day of glucocorticoid (OR 2.220, 95% CI 1.097 to 4.489, p=0.027). Conclusions SILD IV-CYC showed a lower frequency of infection events than high-dose IV-CYC in patients with SLE.
Type of Medium:
Online Resource
ISSN:
2053-8790
DOI:
10.1136/lupus-2022-000779
Language:
English
Publisher:
BMJ
Publication Date:
2022
detail.hit.zdb_id:
2779620-6