In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 86, No. 10 ( 2008-10), p. 682-690
Kurzfassung:
Using mouse peritoneal macrophages, we have examined the mechanism by which Leonurus sibiricus (LS) regulates nitric oxide (NO) production. When LS was used in combination with recombinant interferon-γ (rIFN-γ), there was a marked cooperative induction of NO production; however, LS by itself had no effect on NO production. The increased production of NO from rIFN-γ plus LS-stimulated cells was almost completely inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor κB. Furthermore, treatment of peritoneal macrophages with rIFN-γ plus LS caused a significant increase in tumor necrosis factor-α (TNF-α) production. PDTC also decreased the effect of LS on TNF-α production significantly. Because NO and TNF-α play an important role in immune function and host defense, LS treatment could modulate several aspects of host defense mechanisms as a result of stimulation of the inducible nitric oxide synthase.
Materialart:
Online-Ressource
ISSN:
0008-4212
,
1205-7541
Sprache:
Englisch
Verlag:
Canadian Science Publishing
Publikationsdatum:
2008
ZDB Id:
2004356-9