In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 94, No. 6 ( 2016-06), p. 682-685
Abstract:
The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonary surfactant system. Published data has demonstrated a protective effect of matrix metalloproteinase-3 (Mmp3) deficiency against the inflammatory response associated with ARDS; however, the effect of Mmp3 on physiologic parameters and alterations to surfactant have not been previously studied. It was hypothesized that Mmp3 deficient (Mmp3 −/− ) mice would be protected against lung dysfunction associated with ARDS and maintain a functional pulmonary surfactant system. Wild type (WT) and Mmp3 −/− mice were subjected to acid-aspiration followed by mechanical ventilation. Mmp3 −/− mice maintained higher arterial oxygenation compared with WT mice at the completion of ventilation. Significant increase in functional large aggregate surfactant forms were observed in Mmp3 −/− mice compared with WT mice. These findings further support a role of Mmp3 as an attractive therapeutic target for drug development in the setting of ARDS.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
DOI:
10.1139/cjpp-2015-0377
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2016
detail.hit.zdb_id:
2004356-9
