In:
Journal of Biological Systems, World Scientific Pub Co Pte Ltd, Vol. 22, No. 01 ( 2014-03), p. 73-88
Abstract:
Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insights into the dynamics of human immunodeficiency virus type 1. We built a simple mathematics model to study the effect of latent-infected resting memory CD4+ T cells during the HIV infection and highly active anti-retroviral therapy (HAART). Through analysis of eight patients who received HAART in China, we have an insight into the mechanisms of resting memory CD4+ T cells in HIV infection. Simulations show that new infections still exist in the eight patients even under the HAART. Also, because of the long half-life of resting infected memory CD4+ T cells, removal of HIV from patient could take considerably longer time or be unattainable.
Type of Medium:
Online Resource
ISSN:
0218-3390
,
1793-6470
DOI:
10.1142/S0218339014500041
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2014
detail.hit.zdb_id:
2026740-X
SSG:
12