In:
Journal of Porphyrins and Phthalocyanines, World Scientific Pub Co Pte Ltd, Vol. 20, No. 01n04 ( 2016-01), p. 397-406
Abstract:
An unsymmetrical phthalocyanine based one- and two-photon fluorescence imaging probe that substituted with 4-tert-butylphenoxy and RDGyK moieties was developed and characterized by UV-vis and high-resolution MALDI-TOF/MS. The conjugate is non-aggregated in [Formula: see text],[Formula: see text] -dimethylformamide, with relatively weak fluorescence emission ([Formula: see text] 0.023) and high singlet oxygen quantum yield ([Formula: see text] 0.55). Conjugation of the cyclic peptide sequence c(RGDyK) can enhance the cellular uptake towards the DU145 and PC3 cells. While the fluorescence is greatly enhanced in mitochondria, the conjugate is non-cytotoxicity either in dark or upon exposure to red-light with dose up to 12 J.cm[Formula: see text]. The results suggest that this conjugate is a promising multifunctional imaging probe for mitochondria and cancer.
Type of Medium:
Online Resource
ISSN:
1088-4246
,
1099-1409
DOI:
10.1142/S1088424616500188
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2016