In:
Annual Review of Biochemistry, Annual Reviews, Vol. 90, No. 1 ( 2021-06-20), p. 77-106
Abstract:
The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.
Type of Medium:
Online Resource
ISSN:
0066-4154
,
1545-4509
DOI:
10.1146/biochem.2021.90.issue-1
DOI:
10.1146/annurev-biochem-090120-125407
Language:
English
Publisher:
Annual Reviews
Publication Date:
2021
detail.hit.zdb_id:
1470446-8
SSG:
12