In:
Annual Review of Biomedical Data Science, Annual Reviews, Vol. 6, No. 1 ( 2023-08-10), p. 397-418
Abstract:
Prenatal screening using sequencing of circulating cell-free DNA has transformed obstetric care over the past decade and significantly reduced the number of invasive diagnostic procedures like amniocentesis for genetic disorders. Nonetheless, emergency care remains the only option for complications like preeclampsia and preterm birth, two of the most prevalent obstetrical syndromes. Advances in noninvasive prenatal testing expand the scope of precision medicine in obstetric care. In this review, we discuss advances, challenges, and possibilities toward the goal of providing proactive, personalized prenatal care. The highlighted advances focus mainly on cell-free nucleic acids; however, we also review research that uses signals from metabolomics, proteomics, intact cells, and the microbiome. We discuss ethical challenges in providing care. Finally, we look to future possibilities, including redefining disease taxonomy and moving from biomarker correlation to biological causation.
Type of Medium:
Online Resource
ISSN:
2574-3414
,
2574-3414
DOI:
10.1146/biodatasci.2023.6.issue-1
DOI:
10.1146/annurev-biodatasci-020722-094144
Language:
English
Publisher:
Annual Reviews
Publication Date:
2023