In:
Annual Review of Physiology, Annual Reviews, Vol. 83, No. 1 ( 2021-02-10), p. 107-126
Abstract:
Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca 2+ is a key modulator of both ATP production and cell death. Although mitochondrial Ca 2+ uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca 2+ uptake and efflux have been identified. The identification of the mitochondrial Ca 2+ uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca 2+ is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.
Type of Medium:
Online Resource
ISSN:
0066-4278
,
1545-1585
DOI:
10.1146/physiol.2021.83.issue-1
DOI:
10.1146/annurev-physiol-031920-092419
Language:
English
Publisher:
Annual Reviews
Publication Date:
2021
detail.hit.zdb_id:
1474465-X
SSG:
12
