In:
Annual Review of Genomics and Human Genetics, Annual Reviews, Vol. 5, No. 1 ( 2004-09-22), p. 317-349
Abstract:
▪ Abstract As recently as 20 years ago, there was relatively little information about the number and distribution of recombinational events in human meiosis, and we knew virtually nothing about factors affecting patterns of recombination. However, the generation of a variety of linkage-based genetic mapping tools and, more recently, cytological approaches that enable us to directly visualize the recombinational process in meiocytes, have led to an increased understanding of human meiosis. In this review, we discuss the different approaches used to study meiotic recombination in humans, our understanding of factors that affect the number and location of recombinational events, and clinical consequences of variation in the recombinational process.
Type of Medium:
Online Resource
ISSN:
1527-8204
,
1545-293X
DOI:
10.1146/genom.2004.5.issue-1
DOI:
10.1146/annurev.genom.4.070802.110217
Language:
English
Publisher:
Annual Reviews
Publication Date:
2004
detail.hit.zdb_id:
2033916-1
SSG:
12
