In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 289, No. 5 ( 2005-11), p. E909-E914
Abstract:
The oral glucose minimal model (OMM) measures insulin sensitivity (S I ) and the glucose rate of appearance (R a ) of ingested glucose in the presence of physiological changes of insulin and glucose concentrations. However, S I of OMM measures the overall effect of insulin on glucose utilization and glucose production. In this study we show that, by adding a tracer to the oral dose, e.g., of a meal, and by using the labeled version of OMM, OMM* to interpret the data, one can measure the selective effect of insulin on glucose disposal, [Formula: see text]. Eighty-eight individuals underwent both a triple-tracer meal with the tracer-to-tracee clamp technique, providing a model-independent reference of the R a of ingested glucose ([Formula: see text]) and an insulin-modified labeled intravenous glucose tolerance test (IVGTT*). We show that OMM* provides not only a reliable means of tracing the R a of ingested glucose (R a meal ) but also accurately measures [Formula: see text]. We do so by comparing OMM* R a meal with the model-independent [Formula: see text] provided by the tracer-to-tracee clamp technique, while OMM* [Formula: see text] is compared with both [Formula: see text], obtained by using as known input [Formula: see text] , and with [Formula: see text] measured during IVGTT*.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.00299.2004
Language:
English
Publisher:
American Physiological Society
Publication Date:
2005
detail.hit.zdb_id:
1477331-4
SSG:
12
