In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 198, No. 3 ( 1960-03-01), p. 575-580
Abstract:
In 43 chickens, the mean C inulin was 4.7 ± 1.8 ml/min. (1.8 ± 0.8 ml/kg/min.), mean C urate 29.0 ± 14.9 ml/min. (11.3 ± 6.0 ml/kg/min.) and mean T urate 1.30 ± 0.69 mg/min. (0.48 ± 0.24 mg/kg/min.). Tubular secretion accounted for a mean of 81% of the total urinary urate. Probenecid, sulfinpyrazone, zoxazolamine and high dosages of phenylbutazone, all uricosuric in man, reduced urate excretion in the chicken, apparently by suppressing tubular secretion of urate; C PAH also was reduced. Salicylate, in doses uricosuric in man, had no effect on chicken urate excretion. Pyrazinamide and sodium r-lactate, agents which decrease urate excretion in man, did not alter urate excretion in the chicken. PAH loading experiments demonstrated that as T PAH increased, T urate decreased. These latter findings suggest competition of urate and PAH for renal tubular transport in the chicken.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1960.198.3.575
Language:
English
Publisher:
American Physiological Society
Publication Date:
1960
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12
