In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 201, No. 5 ( 1961-11-01), p. 931-934
Abstract:
Ovariectomized white rats were treated as follows: group 1, 70 µg estradiol benzoate every other day for 9 days; group 2, 3.1 mg aqueous progesterone daily for 4 days then 6.2 mg daily for 5 days; group 3, untreated controls. Spontaneous muscle contractions were recorded isometrically from isolated uterine horns. Uteri from the estrogen-treated animals were the most sensitive to the stimulatory action of oxytocin (5 mu/ml). The action of oxytocin remained essentially unchanged in the presence of a tenfold increase in external K concentration in both the estrogen-treated and progesterone-treated muscles. A reduction in the Ca concentration of the surrounding medium markedly reduced the effectiveness of oxytocin. This decline in oxytocin potency was most pronounced in the estrogen-treated uteri.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1961.201.5.931
Language:
English
Publisher:
American Physiological Society
Publication Date:
1961
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1477334-X
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2065807-2
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1477287-5
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1477308-9
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1477297-8
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1477300-4
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1477329-6
SSG:
12
