In:
Journal of Applied Physiology, American Physiological Society, Vol. 84, No. 5 ( 1998-05-01), p. 1795-1800
Kurzfassung:
In spontaneously hypertensive rats (SHR), chronic infusion of clonidine failed to decrease blood pressure and blood pressure variability. We used nonlinear methods to get a deeper insight on the effects of clonidine on blood pressure dynamics. For 24 h and 4 wk, clonidine (0.1 mg ⋅ kg −1 ⋅ day −1 sc) was infused by minipumps in the conscious SHRs, and, for comparison, a vehicle was infused in SHRs and in Wistar-Kyoto rats. Blood pressure was recorded for 30 min before and after treatments. We used the Lyapunov exponent, approximated by the inverse of the l max index derived from the recurrence plot method, to characterize nonlinear dynamics. Before treatment, l max index of blood pressure was lower ( P 〈 0.01) in the SHRs than in the Wistar-Kyoto rats. Clonidine significantly increased l max ( P 〈 0.01) to the level observed in normotensive rats, at 24 h and up to 4 wk after infusion. We conclude that clonidine has a significant chronic effect on blood pressure dynamics, as evidenced by nonlinear methods. Our study also suggests that the mechanisms governing blood pressure variations are nonlinear.
Materialart:
Online-Ressource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/jappl.1998.84.5.1795
Sprache:
Englisch
Verlag:
American Physiological Society
Publikationsdatum:
1998
ZDB Id:
1404365-8
SSG:
12
SSG:
31
