In:
Journal of Neurophysiology, American Physiological Society, Vol. 114, No. 1 ( 2015-07), p. 1-5
Abstract:
Voltage-dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart ( J Neurosci 33: 19396–19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calcium-activated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals.
Type of Medium:
Online Resource
ISSN:
0022-3077
,
1522-1598
DOI:
10.1152/jn.00181.2014
RVK:
XA 10000 ; XA 552555
Language:
English
Publisher:
American Physiological Society
Publication Date:
2015
detail.hit.zdb_id:
80161-6
detail.hit.zdb_id:
1467889-5
