In:
HPB Surgery, Hindawi Limited, Vol. 5, No. 3 ( 1992-01-01), p. 185-194
Abstract:
Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who
received a constant infusion schedule of 15mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was given during
the hours of 3pm to 9pm then all of the animals survived the 14 day infusion. If the maximum dose of infusion was changed so that 60% of the infusion was given at night from 3am to 9am the infusion
became more toxic and all the animals died in a mean of 5.5 days. Pathologic sectioning of all the livers reflected the above outcomes with the greatest amount of hepatic necrosis in the animals on the night
cycles. This study underscores the recent advances in chronobiology demonstrating that for continuous hepatic arterial infusions the timing of delivery is crucial in determining the toxicity.
Type of Medium:
Online Resource
ISSN:
0894-8569
Language:
English
Publisher:
Hindawi Limited
Publication Date:
1992
detail.hit.zdb_id:
2031561-2
