In:
Clinical and Developmental Immunology, Hindawi Limited, Vol. 2007 ( 2007), p. 1-6
Abstract:
The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF- α , TGF- β 1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF- α ) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF- β 1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF- β 1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.
Type of Medium:
Online Resource
ISSN:
1740-2522
,
1740-2530
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2007
detail.hit.zdb_id:
2817541-4
detail.hit.zdb_id:
2119272-8
