In:
Advances in Artificial Neural Systems, Hindawi Limited, Vol. 2010 ( 2010-08-23), p. 1-11
Abstract:
The aim of this study was to compare multilayer perceptron neural networks (NNs) with standard logistic regression (LR) to identify key covariates impacting on mortality from cancer causes, disease-free survival (DFS), and disease recurrence using Area Under Receiver-Operating Characteristics (AUROC) in breast cancer patients. From 1996 to 2004, 2,535 patients diagnosed with primary breast cancer entered into the study at a single French centre, where they received standard treatment. For specific mortality as well as DFS analysis, the ROC curves were greater with the NN models compared to LR model with better sensitivity and specificity. Four predictive factors were retained by both approaches for mortality: clinical size stage, Scarff Bloom Richardson grade, number of invaded nodes, and progesterone receptor. The results enhanced the relevance of the use of NN models in predictive analysis in oncology, which appeared to be more accurate in prediction in this French breast cancer cohort.
Type of Medium:
Online Resource
ISSN:
1687-7594
,
1687-7608
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2010
detail.hit.zdb_id:
2532254-0
