In:
Journal of Obesity, Hindawi Limited, Vol. 2011 ( 2011), p. 1-8
Abstract:
Background . Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose . Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods . 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results . Body weight was similarly reduced after both months (mean: −8.0 kg, n = 13 ). Relative body fat changes were smaller after LCD than after GBP ( − 7.1 ± 3.6 % versus − 10 ± 3.2 %, P = .029 , n = 13 ). Liver fat fell during the LCD month (−41%, P = .001 , n = 13 ) but was unaltered one month after GBP (+12%). Conclusion . Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed.
Type of Medium:
Online Resource
ISSN:
2090-0708
,
2090-0716
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2573566-4
