In:
Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-7
Abstract:
Aim . Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO 2 reactivity (CVR) in healthy male subjects. Materials and Methods . We examined erythrocyte deformability in an HCEt group ( n = 14 ) and a control group ( n = 10 ). CVR was measured using hyperventilation-induced CO 2 reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group ( n = 11 ). A historical control group ( n = 10 ) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results . HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group ( 2.9 ± 1.1 % versus - 0.6 ± 1.0 %, P = 0.034 ). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group ( 9.1 ± 4.0 % versus - 8.1 ± 4.1 %, P = 0.007 ). The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions . We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt’s effect on cerebral microcirculation.
Type of Medium:
Online Resource
ISSN:
1741-427X
,
1741-4288
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2148302-4
