In:
Chemotherapy Research and Practice, Hindawi Limited, Vol. 2012 ( 2012-07-15), p. 1-10
Abstract:
The therapeutic performance of oxaliplatin can be improved by incorporating the central cis -dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, and in vivo evaluation of core cross-linked micelles loaded with DACHPt. Stable drug-loaded micelles were prepared at high drug loading ( ~ 25 w/w%) and displayed a considerably increased in vitro cytotoxicity compared to free oxaliplatin against A2780 ovarian cancer cells. The DACHPt-loaded micelle formulation was well tolerated in mice and exhibited improved antitumor activity than oxaliplatin alone in an ovarian tumor xenograft model.
Type of Medium:
Online Resource
ISSN:
2090-2107
,
2090-2115
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2603560-1
