In:
Case Reports in Genetics, Hindawi Limited, Vol. 2013 ( 2013), p. 1-3
Kurzfassung:
Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.
Materialart:
Online-Ressource
ISSN:
2090-6544
,
2090-6552
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2013
ZDB Id:
2664417-4
