In:
Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
Abstract:
Aim . To investigate the effects of weight loss during an 8-week very low carbohydrate diet (VLCD) on improvement of metabolic parameters, adipose distribution and body composition, and insulin resistance and sensitivity in Chinese obese subjects. Methods . Fifty-three healthy obese volunteers were given an 8-week VLCD. The outcomes were changes in anthropometry, body composition, metabolic profile, abdominal fat distribution, liver fat percent (LFP), and insulin resistance and sensitivity. Results . A total of 46 (86.8%) obese subjects completed the study. The VLCD caused a weight loss of − 8.7 ± 0.6 kg (mean ± standard error (SE), P 〈 0.0001 ) combined with a significant improvement of metabolic profile. In both male and female, nonesterified fatty acid (NEFA) significantly decreased ( − 166.2 ± 47.6 μ mol/L, P = 0.001 ) and β -hydroxybutyric acid (BHA) increased ( 0.15 ± 0.06 mmol/L, P = 0.004 ) after eight weeks of VLCD intervention. The significant reductions in subcutaneous fat area (SFA), visceral fat area (VFA), and LFP were − 66.5 ± 7.9 cm 2 , − 35.3 ± 3.9 cm 2 , and − 16.4 ± 2.4 %, respectively (all P values P 〈 0.0001 ). HOMA IR and HOMA β significantly decreased while whole body insulin sensitivity index (WBISI) increased (all P values P 〈 0.001 ). Conclusion . Eight weeks of VLCD was an effective intervention in obese subjects. These beneficial effects may be associated with enhanced hepatic and whole-body lipolysis and oxidation.
Type of Medium:
Online Resource
ISSN:
1741-427X
,
1741-4288
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2013
detail.hit.zdb_id:
2148302-4
