In:
Mediators of Inflammation, Hindawi Limited, Vol. 2014 ( 2014), p. 1-15
Abstract:
This study investigated the anti-inflammatory effects of DEC on the CCl 4 -induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl 4 0.5 μ L/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days before finishing the CCl 4 induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1 β , MDA, TGF- β , and α SMA immunopositivity, besides exhibiting decreased IL1 β , COX-2, NF κ B, IFN γ , and TGF β expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation.
Type of Medium:
Online Resource
ISSN:
0962-9351
,
1466-1861
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2014
detail.hit.zdb_id:
2008065-7