In:
Disease Markers, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
Kurzfassung:
Background. PPAR- γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population. Whether PPAR- γ SNPs affect the clinical courses in ESRD patients is unknown. Methods. From a multicenter cohort, we identified 698 patients with prevalent ESRD between 2002 and 2003, and other 782 healthy subjects as control. Two PPAR- γ SNPs, Pro12Ala (rs1801282) and C161T (rs3856806), were genotyped and their association with ESRD was examined. Both groups were prospectively followed until 2007, and the predictability of genotypes for the long-term survival of ESRD patients was analyzed. Results. After multivariable-adjusted regression, GG genotype of Pro12Ala was significantly more likely to associate with ESRD ( P 〈 0.001 ) among patients with non-diabetes-related ESRD. Cox’s proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] 〈 0.01; P 〈 0.001 ; for C161T, CC versus TT genotypes, HR 2.86; P 〈 0.001 ; CT versus TT genotypes, HR 1.93; P 〈 0.001 ). Conclusion. This is the first and largest study to evaluate PPAR- γ SNPs in ESRD patients. Further mechanistic study is needed to elucidate the role of PPAR- γ among ESRD patients.
Materialart:
Online-Ressource
ISSN:
0278-0240
,
1875-8630
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2015
ZDB Id:
2033253-1
