In:
Case Reports in Nephrology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-3
Abstract:
Background . Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report . Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud’s syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μ mol/L in a few months and AKI was diagnosed. Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome. Histological analysis found granulomatous interstitial nephropathy without necrosis in 20% of the kidney biopsy without immunofluorescent deposit. Nifedipine was stopped and corticosteroid treatment was started with a rapid but incomplete reduction of serum creatininemia level to 106 μ mol/L. Conclusion . This is the first case of AIN caused by nifedipine.
Type of Medium:
Online Resource
ISSN:
2090-6641
,
2090-665X
DOI:
10.1155/2016/1971465
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2627652-5
