In:
Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
Kurzfassung:
Background . Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders. However, little is known regarding the effect of antioxidant SNPs on renal events. Methods . We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR- γ (Pro12Ala, C161T) genotyped. Multiple regression analyses were conducted to evaluate the significant risk determinants for ESRD. Results . Compared to ESRD patients, non-CKD subjects were more likely to have T allele at SOD2 Val16Ala ( p = 0.036 ) and CC genotype at PPAR- γ Pro12Ala ( p = 0.028 ). Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0.699; p = 0.018 ). GPX1 SNP alone did not alter the risk. We detected significant interactions between SNPs including PPAR- γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD. Conclusion . This is the first and largest study on the association between adverse renal outcomes and antioxidant SNPs among Han Chinese population. Determination of SOD2 and PPAR- γ SNPs status might assist in ESRD risk estimation.
Materialart:
Online-Ressource
ISSN:
1942-0900
,
1942-0994
DOI:
10.1155/2016/8516748
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2016
ZDB Id:
2455981-7