In:
Case Reports in Immunology, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
Abstract:
Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding g p 91 p h o x protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus . In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA gene mutation affecting p 22 p h o x protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.
Type of Medium:
Online Resource
ISSN:
2090-6609
,
2090-6617
DOI:
10.1155/2017/2676403
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2695564-7