In:
Bioinorganic Chemistry and Applications, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
Abstract:
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.
Type of Medium:
Online Resource
ISSN:
1565-3633
,
1687-479X
DOI:
10.1155/2017/4736321
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2213020-2