In:
Mediators of Inflammation, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
Abstract:
Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3 + , CD4 + , CD8 + , CD4 + PD-1 + , and CD8 + PD-1 + T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4 + PD-1 + and CD8 + PD-1 + T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4 + PD-1 + or CD8 + PD-1 + T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.
Type of Medium:
Online Resource
ISSN:
0962-9351
,
1466-1861
DOI:
10.1155/2017/5385102
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2008065-7