In:
Journal of Chemistry, Hindawi Limited, Vol. 2018 ( 2018-07-16), p. 1-10
Abstract:
Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. The structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier transformed infrared (FTIR), 1 H, 13 C, and 31 P{ 1 H} NMR spectroscopy, and thermogravimetric analysis (TGA). A bidentate phosphine ligand acted as a chelating agent which bond to the silver in 1 : 2 molar ratios. Meanwhile, thiazolidine was attached to the silver in a 1 : 1 molar ratio. The antiplasmodial properties of all synthesized complexes were investigated on chloroquine-resistant P. falciparum parasite via HRP2 assays and cytotoxicity tests on Vero cells. Of all the synthesized complexes, complex 2 showed the highest SI value (more than 12.4) followed by complex 5 (6.6). The potent properties of compounds 2 and 5 were also noted in the in vitro antiproliferative assays involving MDA-MB-231 and MCF-7 breast cancer cell lines as well as HT-29 colon cancer cell line. Complex 2 was selective for MDA-MB-231 cells (GI 50 = 1.9 ± 0.3 µ M), while complex 5 acted predominantly on breast carcinoma cells (GI 50 MDA-MB-231 = 4.7 ± 1.1 µ M; MCF-7 = 2.9 ± 0.9 µ M) instead of colon carcinoma (HT-29) cells (GI 50 = 15.1 ± 1.9 µ M).
Type of Medium:
Online Resource
ISSN:
2090-9063
,
2090-9071
DOI:
10.1155/2018/8395374
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2018
detail.hit.zdb_id:
2393625-3
detail.hit.zdb_id:
2703077-5
