In:
BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-12-25), p. 1-8
Abstract:
Aim. To compare the effects of once-weekly Dulaglutide with once-daily glargine in poorly oral-antidiabetic controlled patients with type 2 diabetes mellitus (T2DM). Method. A total of 25 patients with T2DM admitted into Department of Endocrinology from December 2012 to August 2013 were randomly assigned into two groups: Dulaglutide group ( n = 16 ) and glargine group ( n = 9 ). All patients received either Dulaglutide or glargine treatments for 52 weeks. Continuous glucose monitoring systems (CGMS) were applied to them for two 72 h periods at before and after the treatment each. Patient general clinical data were collected and analyzed. Result. Fast blood glucose ( FBG) of the glargine group declined more significantly than the Dulaglutide group after treatment ( p 〈 0.05 ). The mean blood glucose (MBG), standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursion (MAGE) within a day, the largest amplitude of glycemic excursion (LAGE), M -value, absolute means of daily difference (MODD) of glycemic excursion, the percentage of time (≤2.8 mmol/L, ≤3.9 mmol/L, ≥10.0 mmol/L, ≥13.9 mmol/L, 3.9–7.8 mmol/L, and 9–10.0 mmol/L), maximum glycemic value, and minimum glycemic value were similar between the two groups ( p 〉 0.05 ). The incidence of hypoglycemia was also similar between the two groups ( p 〉 0.05 ). Though serum levels of TNF- α , IL-6, and 8-PGF2 α all decreased, significant reduction was found in TNF- α and 8-PGF2 α . TNF- α was only significantly reduced in the Dulaglutide group, while 8-PGF2 α was seen in both groups. Conclusion. For T2DM patients with poorly controlled oral antidiabetic drugs, once-weekly Dulaglutide not only has the same effect on glucose fluctuation as once-daily glargine but also significantly reduced TNF- α and 8-PGF2 α after a 52 week treatment protocol. This trial is registered with ClinicalTrials.gov NCT01648582 .
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2019/2682657
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2019
detail.hit.zdb_id:
2698540-8
