In:
Disease Markers, Hindawi Limited, Vol. 2019 ( 2019-11-16), p. 1-6
Kurzfassung:
Objective . Intrauterine growth restriction (IUGR) is a major cause of late stillbirth, though not all compromised babies remain small or are considered growth restricted as pregnancy progresses. Fetal Magnetic Resonance Imaging (f-MRI) represents a second-line tool to study pregnancies with IUGR fetuses. The aim of our study was to evaluate the usefulness of f-MRI on predicting fetal growth and the offspring’s perinatal respiratory outcome. Design . All f-MRI performed between 2014 and 2016 in Siena were analysed. Pregnancies with IUGR (Study group (SG)) were recruited together with a control population (Control group (CG)), coupled for gestational age (GA) at the time of f-MRI (mean GA 31 wks). Neonatal information was collected. The f-MRI protocol consisted of T2w images. Six regions of interest (ROI) were placed as follows: 2 on the lung, 2 on the liver, and 2 on the amniotic fluid. The signal intensities (SI) of each ROI were measured. The SI lung to liver ratio (SI lung/liver) and SI lung to amniotic fluid ratio (SI lung/amniotic fluid) were obtained for each fetus. Each ratio was compared between SG and CG. Therefore, SG was divided into two subgroups: adequate and small for gestational age (AGA and SGA) newborns. All measurements were related to offspring’s perinatal respiratory outcome. Results . SI lung/liver was linearly related with GA at the time of f-MRI and with EFW. SI lung/amniotic fluid was significantly higher in SG than in CG ( p = 0,014 ). In contrast, among SG, lower values of SI lung/amniotic fluid were found in the SGA compared to AGA ( p = 0,036 ). The days of oxygen supply were higher in the SGA subgroup than in the AGA subgroup ( p = 0,028 ). Conclusions . SI lung/liver increases with fetal lung maturation and appears to be useful to estimate intrauterine fetal growth. SI lung/amniotic fluid seems to be a reliable predictive index to distinguish the IUGR fetuses that can recover their growth from those that were born SGA. f-MRI represents a promising frontier to predict IUGR fetus outcome, thus contributing to ameliorate the perinatal management.
Materialart:
Online-Ressource
ISSN:
0278-0240
,
1875-8630
DOI:
10.1155/2019/4373490
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2019
ZDB Id:
2033253-1
