In:
Disease Markers, Hindawi Limited, Vol. 2021 ( 2021-10-22), p. 1-9
Abstract:
Aim. Carbapenem-resistant Klebsiella pneumoniae- (CR-Kp-) mediated infections represent a challenge for clinical practitioners due to their expanding prevalence in hospital environments and antibiotic resistance. However, few studies have shown metabolic changes of carbapenem-resistant Klebsiella pneumoniae and CR-Kp-negative patients, and relevant studies are urgently needed. Methods. In this study, we comprehensively profile the metabolites of 20 CR-Kp-positive and 18 CR-Kp-negative patients in plasma by using 2D gas chromatography–time-of-flight mass spectrometry (GC×GC-TOFMS). Results. We identified 58 metabolites that were carbapenem-resistant Klebsiella pneumoniae-associated. N-Acetyl glucosamine, butanedioic acid, and myoinositol play a significant character in CR-Kp infection. Conclusions. Our study provides valuable data to serve as potential targets for developing therapies against CR-Kp infection.
Type of Medium:
Online Resource
ISSN:
1875-8630
,
0278-0240
DOI:
10.1155/2021/7155772
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2021
detail.hit.zdb_id:
2033253-1
