In:
The Scientific World Journal, Hindawi Limited, Vol. 2021 ( 2021-12-13), p. 1-12
Abstract:
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models.
Type of Medium:
Online Resource
ISSN:
1537-744X
,
2356-6140
DOI:
10.1155/2021/7479540
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2021
detail.hit.zdb_id:
2075968-X