In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 64, No. 10 ( 2004-05-15), p. 3391-3394
Kurzfassung:
Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are ∼100-fold more resistant to killing by SN1 type methylating agents than MMR-proficient controls, the sensitivity differences reported for the other agents were typically & lt;2-fold. To test whether these differences were linked to factors other than MMR status, we studied the cytotoxicities of mitomycin C, chloroethylcyclohexyl nitrosourea, melphalan, psoralen-UVA, etoposide, camptothecin, ionizing radiation, and cis-dichlorodiaminoplatinum (cisplatin) in a strictly isogenic system. We now report that MMR deficiency reproducibly desensitized cells solely to cisplatin.
Materialart:
Online-Ressource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/0008-5472.CAN-04-0513
Sprache:
Englisch
Verlag:
American Association for Cancer Research (AACR)
Publikationsdatum:
2004
ZDB Id:
2036785-5
ZDB Id:
1432-1
ZDB Id:
410466-3
