In:
Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 19, No. 11 ( 2010-11-01), p. 2839-2846
Kurzfassung:
Background: The apolipoprotein E gene (apoE) has three major isoforms encoded by the ϵ2, ϵ3, and ϵ4 alleles, with the ϵ4 allele associated with hypercholesterolemia and the ϵ2 allele with the opposite effect. An inverse relationship between cholesterolemia and head and neck cancer (HNC) has been previously reported, although the relationship between apoE genotypes and HNC has not been explored to date. Methods: Four hundred and seventeen HNC cases and 436 hospital controls were genotyped for apoE polymorphisms. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) from logistic regression were used to explore the relationship between HNC and putative risk factors. A gene-environment interaction analysis was done. Results: A borderline significant 40% decreased HNC risk (OR, 0.58; 95% CI, 0.31-1.05) was observed for individuals carrying at least one ϵ2 allele. Females carrying at least one ϵ2 allele showed a 60% risk reduction (OR, 0.43; 95% CI, 0.21-0.90) for HNC compared with ϵ3 homozygotes. A statistically significant interaction was found between alcohol use and the ϵ4 allele (P for interaction = 0.04), with a 2-fold increased risk (OR, 2.06; 95% CI, 0.95-4.48) among ever drinkers with an ϵ4 allele, with respect to ϵ3 homozygote nondrinkers. Conclusions: Our study provides novel evidence of a possible protective effect of the ϵ2 allele against HNC, probably due to its increased antioxidant properties. Impact: According to our results, apolipoprotein E may play a different role in carcinogenesis other than its well-known role in regulating blood serum cholesterol levels. Cancer Epidemiol Biomarkers Prev; 19(11); 2839–46. ©2010 AACR.
Materialart:
Online-Ressource
ISSN:
1055-9965
,
1538-7755
DOI:
10.1158/1055-9965.EPI-10-0624
Sprache:
Englisch
Verlag:
American Association for Cancer Research (AACR)
Publikationsdatum:
2010
ZDB Id:
2036781-8
ZDB Id:
1153420-5
