In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 74, No. 19_Supplement ( 2014-10-01), p. 2192-2192
Abstract:
Few therapeutic options are currently available to treat metastasis to distant organs (e.g., liver) in colorectal cancer (CRC) and breast cancer (BC) patients. To gain insight into the genetic and molecular underpinnings of metastasis, we performed whole-exome sequencing on paired primary and metastasis samples from 5 CRC and 2 BC patients and focused sequencing on additional 13-paired tumors to identify and validate somatic genetic alterations. The results showed that the mutational spectra of metastases were highly heterogeneous. Nevertheless, genetic aberrations in calcium signaling pathway genes (GPR98, SYT6, TACR3, CYSLTR1, RYR3, and CACNA1A) were somatically mutated in liver metastases in 25% of CRC and BC cases, indicating that calcium-dependent signaling plays a key role in distant metastasis. These results begin to define the genetic basis underlying liver metastasis from CRC/BC and identify potential therapeutic targets. Citation Format: Fangfang Song, Miao Li, Yuexin Liu, Fengju Song, Wei Zhang, Kexin Chen. Defective calcium signaling pathway highlights the mutational landscapes of liver metastasis from colorectal and breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2192. doi:10.1158/1538-7445.AM2014-2192
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2014-2192
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2014
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
