In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 5283-5283
Abstract:
Prostate cancer (PCa) is a leading cause of cancer death in US men. Yet, the etiology of prostate cancer remains poorly understood, with only older age, African ancestry, family history of the disease, and multiple germline genetic variations being established disease risk factors. Prostate cancer occurs more often in African-American (AA) men and Caribbean men of African descent than in men of other race/ethnicities. While it has been previously suggested that obesity (measured using body mass index [BMI, kg/m2]) may worsen disease-related outcomes among prostate cancer patients, the relationship of obesity and prostate cancer risk, using race as a predictor, has not been fully explored. Using multivariable logistic regression, we estimated the risk of total PCa for 976 cases and 1,032 age-matched controls, with equal proportions of European-American (EA) and AA men. Among men in the NCI Maryland Prostate Cancer Case-Control Study, BMI was inversely associated with disease outcomes in AA men, but not among EA men. Consistent with previous literature, BMI in EA men was shown to be positively associated with overall prostate cancer risk. Our findings suggest an obesity paradox, where obesity may protect against incidence of PCa among AA men. Studies are needed to elucidate the underlying mechanisms responsible for the differential effects of obesity in AA and EA men with prostate cancer. Citation Format: Margaret S. Pichardo, Cheryl J. Smith, Wei Tang, Tiffany Dorsey, Stefan Ambs. Association between body mass index and prostate cancer among African American men [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5283. doi:10.1158/1538-7445.AM2017-5283
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2017-5283
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2017
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
