In:
Cytogenetic and Genome Research, S. Karger AG, Vol. 89, No. 3-4 ( 2000), p. 209-213
Kurzfassung:
〈 abstitle 〉 Abstract. By fluorescence in situ hybridization (FISH) using mouse probes, we assigned homologues for cathepsin E ( 〈 i 〉 Ctse 〈 /i 〉 ), protocadherin 10 ( 〈 i 〉 Pcdh10, 〈 /i 〉 alias OL-protocadherin, 〈 i 〉 Ol-pc 〈 /i 〉 ), protocadherin 13 ( 〈 i 〉 Pcdh13 〈 /i 〉 , alias protocadherin 2c, 〈 i 〉 Pcdh2c 〈 /i 〉 ), neuroglycan C ( 〈 i 〉 Cspg5 〈 /i 〉 ) and myosin X ( 〈 i 〉 Myo10 〈 /i 〉 ) genes to rat chromosomes (RNO) 13q13, 2q24→q25, 18p12→p11, 8q32.1 and 2q22.1→q22.3, respectively. Similarly, homologues for mouse 〈 i 〉 Ctse 〈 /i 〉 , 〈 i 〉 Pcdh13 〈 /i 〉 , 〈 i 〉 Cspg5 〈 /i 〉 and 〈 i 〉 Myo10 〈 /i 〉 genes and homologues for rat Smad2 ( 〈 i 〉 Madh2 〈 /i 〉 ) and Smad4 ( 〈 i 〉 Madh4 〈 /i 〉 ) genes were assigned to Chinese hamster chromosomes (CGR) 5q28, 2q17, 4q26, 2p29→p27, 2q112→q113 and 2q112→q113, respectively. The chromosome assignments of homologues of 〈 i 〉 Ctse 〈 /i 〉 and 〈 i 〉 Cspg5 〈 /i 〉 reinforced well-known homologous relationships among mouse chromosome (MMU) 1, RNO 13 and CGR 5q, and among MMU 9, RNO 8 and CGR 4q, respectively. The chromosome locations of homologues for 〈 i 〉 Madh2 〈 /i 〉 , 〈 i 〉 Madh4 〈 /i 〉 and 〈 i 〉 Pcdh13 〈 /i 〉 genes suggested that inversion events were involved in chromosomal rearrangements in the differentiation of MMU 18 and RNO 18, whereas most of MMU 18 is conserved as a continuous segment in CGR 2q. Furthermore, the mapping result of 〈 i 〉 Myo10 〈 /i 〉 and homologues suggested an orthologous segment of MMU 15, RNO 2 and CGR 2.
Materialart:
Online-Ressource
ISSN:
1424-8581
,
1424-859X
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2000
ZDB Id:
2061918-2
SSG:
12
