In:
Neuroendocrinology, S. Karger AG, Vol. 67, No. 4 ( 1998), p. 330-335
Kurzfassung:
We investigated the effect of selective inhibition of magnocellular arginine vasopressin (AVP) and oxytocin neurons on histamine (HA)- and restraint-stress-induced adrenocorticotropin (ACTH) and prolactin (PRL) secretion in conscious male rats. The inhibition of magnocellular neurons was obtained by inducing chronic hypoosmolality via continuous exposure of the rats to the AVP V 〈 sub 〉 2 〈 /sub 〉 receptor agonist 1-deamino(8- 〈 i 〉 D 〈 /i 〉 -arginine)vasopressin (DDAVP) which was released from osmotic pumps implanted subcutaneously. In DDAVP-treated rats, plasma osmolality and sodium concentration were 273 mosm/l and 130 mmol/l, respectively. In control rats, the corresponding values were 291 mosm/l and 139 mmol/l. HA (270 nmol) administered intracerebroventricularly or 5 min of restraint stress stimulated ACTH and PRL secretion 4- to 11-fold in normoosmolar rats. In hypoosmolar rats, the HA-induced ACTH response was inhibited more than 40% whereas the restraint-stress-induced ACTH response was unaffected. Conversely, the PRL response to HA in hypoosmolar rats was unaffected whereas the PRL response to restraint stress was inhibited by 40%. In summary, chronic hypoosmolality inhibits HA-induced ACTH and restraint-stress-induced PRL secretion indicating involvement of magnocellular AVP in these responses.
Materialart:
Online-Ressource
ISSN:
0028-3835
,
1423-0194
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1998
ZDB Id:
1483028-0
