In:
Neuropsychobiology, S. Karger AG, Vol. 45, No. 3 ( 2002), p. 128-130
Abstract:
The dopaminergic and glutamate systems have been implicated in cognitive function. We tested the associations between the dopamine D2 receptor 〈 i 〉 (DRD2) 〈 /i 〉 and N-methyl- 〈 i 〉 D 〈 /i 〉 -aspartate receptor 2B subunit 〈 i 〉 (GRIN2B) 〈 /i 〉 gene variants and intelligence quotient (IQ). Subjects with the DRD2 A1/A1 genotype had a significantly higher mean performance IQ than A2/A2 carriers, while no significant differences in IQ scores were determined for the three 〈 i 〉 GRIN2B 〈 /i 〉 genotype groups. These results suggest that genetic variants of the 〈 i 〉 DRD2 〈 /i 〉 gene may play a role in cognitive function. Considering the major role played by the dopaminergic system in general cognitive function, genetic variants of the dopamine receptors and those involved in metabolism and modulation of reuptake should be tested to improve gene-based prediction of general cognitive function.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2002
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3