In:
Oto-Rhino-Laryngologia Nova, S. Karger AG, Vol. 11, No. 3-4 ( 2001), p. 186-192
Kurzfassung:
〈 i 〉 Objectives: 〈 /i 〉 The assessment of the expression patterns of cytokeratin polypeptides (Cks) and vimentin in normal epithelium of the mobile tongue and floor of the mouth, squamous cell carcinomas and their lymph node metastases. 〈 i 〉 Material and Methods: 〈 /i 〉 Chain-specific monoclonal antibodies to various Cks and vimentin were used, employing the immunoperoxidase technique. 〈 i 〉 Results and Conclusions: 〈 /i 〉 Profound changes in the expression of pre-existing Cks and de novo expression of simple epithelium-related Cks and of vimentin occurred upon malignant transformation and tumor progression. Changes were mainly related to the degree of cellular differentiation, tumor cell morphology and tumor growth pattern. Low-grade tumors showed a pronounced decrease of the stratification Cks 4 and 13, and an increase of Cks 14, 16, and 17. With increasing tumor grade, expression of Cks 16 and 17 decreased. De novo expression of Cks 8 and 18 and of vimentin was most marked in high-grade tumors, in tumors with a basaloid phenotype and in tumors growing in small infiltrating tumor fields; it was proposed to be associated with poor prognosis.
Materialart:
Online-Ressource
ISSN:
1014-8221
,
1423-0283
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2001
ZDB Id:
1483536-8
